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The lognormal signal distribution of high-sensitivity Applied Biosystems AB1700 transcriptome data needs to be represented by two independent distributions (Noth et al. 2006b). Furthermore, the signal-dependent variance distribution also is a non-trivial function of signal intensity. We presented a combined signal/variance distribution model for AB1700 data. This model can be efficiently used to generate synthetic datasets with virtually identical statistical properties when compared to actual data using the JAVA application creator 1.0

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